蘇益仁 | 南臺科技大學生物與食品科技系

:::

蘇益仁

姓名	蘇益仁	職稱	講座教授
校內分機	( 06 )-2533131 # 3938
辦公室	I棟905室
E - mail	suihjen0704@stust.edu.tw
最高學歷	台大醫學院病理學博士

研究領域

＊Drug development for ageing and Alzeimer’s disease

＊Development of natural products for metabolic syndrome and rejuvenation

＊Pathogenesis and mechanism of HBV pre-S mutants and hepatocarcinogenesis.

＊Pathogenesis and therapy of virus-associated human cancers

經歷

國家衛生研究院感染症與疫苗研究所國家衛生研究院感染症與疫苗研究所

所長（2002-2008；2011-2013）及特聘研究員（2002-2015）

衛生署疾病管制局局長（2003-2004），成功控制了SARS疫情

國立臺灣大學醫學院病理部主任、病理研究所所長（2000-2002）

國立成功大學醫學院臨床醫學研究所所長、附設醫院病理部主任（1995-2000）

獲獎榮譽

2006	Ho-Chi-Min Award, Ho-Chi-Min City, Vietnam
2005	First Rank Medical Service Award ( SARS control ), Department of Health
2005	Outstanding & Distinguished Award for researches, National Science Council
2003	Outstanding Alumni Award, National Tainan First Senior High School, Tainan
2001	Lai-Ho award for medical service
1999	Outstanding Research Award, National Science Council
1997	Outstanding Research Award, National Science Council
1997	Dr. Tu Tsong-Ming Best Paper Award, Journal of Formosa Medical Association
1995	Outstanding Research Award, National Science Council
1994	Outstanding Award in Cancer Research, Dr..Chien-Tien Hsu
1994	Gold Medal Award in Medical Publication, National News Agency (Diagnosis and Treatment of Malignant Lymphoma)
1990	National Ten Outstanding Young Person (TOYP) Award (Medical Research)
1990	Outstanding Research Award, National Science Council
1989	Professor Shu Yeh’s Award in Pathology (Ph.D. Section)
1987	Phi Tau Phi (Phi Beta Kappa) Award and Membership, National Taiwan University, Taipei, Taiwan
1987	Research Fellowship (1-Fo5-TW 03962) Award, NIH (USA) Fogarty International Center
1986	Professor Shu Yeh’s Award in Pathology for Out-standing Pathology Research
1985	Outstanding Medical Research Award, The Formosan Physician Association
1981	Government Scholarship for Studying Abroad in Pathology, Ministry of Education
1978	Professor Shu Yeh’s Award in Pathology (Graduate Student section)

期刊論文 ( 近五年 )
日期	題名	關聯
2016-04	Hospital-based surveillance of enterovirus 71 in HCM City, Vietnam, 2011-2014	International Journal of Infectious Diseases. 2016 Apr;45(Suppl. 1):303.
2016-03-26	Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma	Oncotarget. 2016 Mar 26;Article in Press.
2016-03-16	Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability	Oncotarget. 2016 Mar 16;Article in Press.
2016-01	A biphasic response pattern of lipid metabolomics in the stage progression of hepatitis B virus X tumorigenesis	Molecular Carcinogenesis. 2016 Jan;55(1):105-114.
2015-12	Genetic diversity of the Mycobacterium tuberculosis East African-Indian family in three tropical Asian countries	Journal of Microbiology, Immunology and Infection. 2015 Dec;Article in Press.
2015-11	Mapping enterovirus A71 antigenic determinants from viral evolution	Journal of Virology. 2015 Nov;89(22):11500-11506.
2015-09	Viral Respiratory Tract Infections in adult patients attending outpatient and emergency departments, Taiwan, 2012-2013: A PCR/electrospray ionization mass spectrometry study	Medicine. 2015 Sep;94(38):Article number e1545.
2015-08-17	A clinical algorithm to identify HIV patients at high risk for incident active tuberculosis: A prospective 5-year cohort study	PLoS ONE. 2015 Aug 17;10(8):Article number e0135801.
2015-07	Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis	Journal of Pathology. 2015 Jul;236(3):337-347.
2015-06	Prevalence of Mycobacterium tuberculosis strain genotypes in Taiwan reveals a close link to ethnic and population migration	Journal of the Formosan Medical Association. 2015 Jun;114(6):484-488.
2015-05	HER2 testing in breast cancer by quantitative PCR: Technical and clinical considerations	Journal of Clinical Oncology. 2015 May;33(15, Suppl.):e11619.
2015-04-24	Hepatitis B Virus Pre-S2 mutant Induces aerobic glycolysis through mammalian target of rapamycin signal cascade	PLoS ONE. 2015 Apr 24;10(4):Article number e0122373.
2015-04-23	Genome sequences of three helicobacter pylori strains from patients with gastric mucosa-associated lymphoid tissue lymphoma	Genome Announcements. 2015 Apr 23;3(2):Article number e00229-15
2015-04-13	Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system	Scientific Reports. 2015 Apr 13;5:Article number 9718.
2015-03-23	Evaluation of MDCK cell-derived influenza H7N9 vaccine candidates in ferrets	PLoS ONE. 2015 Mar 23;10(3):Article number e0120793.
2015-02	Long-term results of a phase II trial with frontline concurrent chemoradiotherapy followed by consolidation chemotherapy for localized nasal natural killer/T-cell lymphoma	European Journal of Haematology. 2015 Feb;94(2):130-137.
2015-01-28	Molecular epidemiology of tuberculosis in Kaohsiung city located at southern Taiwan, 2000-2008	PLoS ONE. 2015 Jan 28;10(1):Article number e0117061.
2015-01	Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis	Journal of Virology. 2015 Jan;89(1):605-614.
2014-12	Recombinant Bacille Calmette-Geurin coexpressing Ag85b, CFP10 and IL-12 elicits effective protection against Mycobacterium tuberculosis	Journal of Microbiology, Immunology and Infection. 2014 Dec;Article in Press.
2014-11-13	Distinct modes of transmission of tuberculosis in aboriginal and non-aboriginal populations in Taiwan	PLoS ONE. 2014 Nov 13;9(11):Article number e0112633.
2014-11	The response of patients with epstein-barr virus - associated hemophagocytic lymphohistiocytosis to HLH-2004 protocol in the initial therapy	Pediatric Blood and Cancer. 2014 Nov;61(11):2134-2135.
2014-10-15	The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis	Journal of Biomedical Science. 2014 Oct 15;21:Article number 98.
2014-09	Pathogenesis of virus-associated human cancers: Epstein-Barr virus and hepatitis B virus as two examples	Journal of the Formosan Medical Association. 2014 Sep;113(9):581-590.
2014-09	Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis	Autophagy. 2014 Sep;10(9):1687-1689.
2014-09	Early dexamethasone treatment exacerbates enterovirus 71 infection in mice	Virology. 2014 Sep;464-465(1):218-227.
2014-09	Draft genome sequences of the Mycobacterium tuberculosis clinical strains A2 and A4, isolated from a relapse patient in Taiwan	Genome Announcements. 2014 Sep;2(5):Article number e00672-14.
2014-07-14	Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells	International Journal of Molecular Sciences. 2014 Jul 14;15(7):12442-12457.
2014-06-05	Draft genome sequence of the mycobacterium tuberculosis clinical isolate C2, belonging to the Latin American-Mediterranean family	Genome Announcements. 2014 Jun 5;2(3):Article number e00536-14.
2014-06	Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis	Human Pathology. 2014 Jun;45(6):1294-1301.
2014-05	Hematopathologic discrepancies between referral and review diagnoses: A gap between general pathologists and hematopathologists	Leukemia & Lymphoma. 2014 May;55(5):1023-1030.
2014-05	Ground glass hepatocytes coexpressing hepatitis B virus X protein and surface antigens effect on oncogenic effects and tumorigenesis	Journal of Clinical Oncology. 2014 May;32(15, Suppl.):e15115.
2014-04-26	Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71	Journal of Biomedical Science. 2014 Apr 26;21:Article number 33.
2014-04	Molecular epidemiology of Mycobacterium tuberculosis in aboriginal peoples of Taiwan, 2006-2011	Journal of Infection. 2014 Apr;68(4):332-337.
2014-04	Rapid identification of bacteria and candida pathogens in peritoneal dialysis effluent from patients with peritoneal dialysis-related peritonitis using multilocus PCR coupled with electrospray ionization mass spectrometry	Journal of Clinical Microbiology. 2014 Apr;52 (4):1217-1219.
2014-02	Identification of fungal pathogens from clinical specimens using multi-locus PCR coupled with electrospray ionization mass spectrometry	Diagnostic Microbiology and Infectious Disease. 2014 Feb;78(2):141-143.
2013-12	Dissemination of multidrug-resistant Acinetobacter baumannii carrying BlaOxA-23 from hospitals in central Taiwan	Journal of Microbiology, Immunology and Infection. 2013 Dec;46(6):419-424.
2013-12	Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implication for viral hepatocarcinogenesis	Journal of Virology. 2013 Dec;87(23):12675-12684.
2013-12	Lessons we learn from hematopathology consultation in Taiwan	Journal of the Formosan Medical Association. 2013 Dec;112(12):738-748.
2013-11-21	Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers	PLoS ONE. 2013 Nov 21;8(11):Article number e79783.
2013-11	Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide	Molecular Cancer Therapeutics. 2013 Nov;12(11):2505-2516.
2013-11	Prediction of the risk of active tuberculosis in HIV-infection with an interferon-γ release assay	Lancet. 2013 Nov;382(Suppl. 2):S16.
2013-11	Hepatitis B virus pre-S2 mutant stimulates aerobic glycolysis through mammalian target of rapamycin signaling in tumorigenesis	Molecular Cancer Therapeutics. 2013 Nov;12(11, Suppl.):A168.
2013-09-20	High-incidence of human adenoviral co-infections in Taiwan	PLoS ONE. 2013 Sep 20;8(9):Article numbere75208.
2013-09	Chemoprevention of HBV-related hepatocellular carcinoma by the combined product of resveratrol and silymarin in transgenic mice	Functional Foods in Health and Disease. 2013 Sep;3(9):341-352.
2013-08	Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor	Histopathology. 2013 Aug;63(2):225-233.
2013-08	Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224	Hepatology. 2014 Feb;59(2):505-517.
2013-07-29	Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011	PLoS ONE. 2013 Jul 29;8(7):Article number e69895.
2013-07	Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: A randomized controlled trial	Critical Care Medicine. 2013 Jul;41(7):1754-1760.
2013-07	WW domain-containing oxidoreductase is involved in upregulation of matrix metalloproteinase 9 by Epstein-Barr virus latent membrane protein 2A	Biochemical and Biophysical Research Communications. 2013 Jul;436(4):672-676.
2013-07	Incidence and outcome of newly-diagnosed tuberculosis in schizophrenics: a 12-year, nationwide, retrospective longitudinal study	BMC Infectious Diseases. 2013 Jul;13:Article number 351.
2013-06	Use of PCR coupled with electrospray ionization mass spectrometry for rapid identification of fungal pathogens in invasive mold diseases	International Journal of Antimicrobial Agents. 2013 Jun;42(Suppl. 2):S100.
2013-06	Adenovirus respiratory infections in Taiwanese children, 2002-2011	International Journal of Antimicrobial Agents. 2013 Jun;42(Suppl. 2):S149.
2013-05	Enterovirus 71 infection increases expression of interferon-gamma-inducible protein 10 which protects mice by reducing viral burden in multiple tissues	Journal of General Virology. 2013 May;94(Pt 5):1019-1027.
2013-05	A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine	Vaccine. 2013 May;31(20):2471-2476.
2013-02	Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis B virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients	Carcinogenesis. 2013 Feb;34(2):475-485.
2013-02	Chemoprevention and novel therapy for hepatocellular carcinoma associated with chronic hepatitis B virus infection	Hepatobiliary Surgery and Nutrition. 2013 Feb;2(1):37-39.
2012-12	Production of EV71 vaccine candidates	Human Vaccine Immunotherapy. 2012 Dec;8(12):1775-1783.
2012-11-30	Immunological and biochemical characterization of Coxsackie Virus A16 viral particles	PLoS ONE. 2012 Nov 30;7(11):Article number e49973.
2012-11-01	寡核苷酸用於偵測B型肝炎病毒Pre-S區域缺失及其用途	I375723/2012-11-01
2012-11	CD4 T-cell-independent antibody response reduces Enterovirus 71 lethality in mice by decreasing tissue viral loads	Clinical and Developmental Immunology. 2012 Nov;2012:Article ID 580696.
2012-10-23	Oligonucleotides and use thereof for determining deletion in HBV pre-S region	US8293474B2/2012-10-23
2012-10	Ground glass hepatocytes co-express HBx and pre-S mutants and represent precursor lesions of HBV-related hepatocellular carcinoma: implication for chemoprevention	Histopathology. 2012 Oct;61(Suppl. 1):94-95.
2012-10	Front-line concurrent chemoradiotherapy (CCRT) followed consolidation chemotherapy in localized nasal NK/T-cell lymphoma	Annals of Oncology. 2012 Oct;23(Suppl. 11):93.
2012-08-28	Challenges to licensure of enterovirus 71 vaccines	PLoS Neglected Tropical Diseases. 2012 Aug 28;6(8):Article number e1737.
2012-08-24	Clonal expansion of both modern and ancient genotypes of Mycobacterium tuberculosis in southern Taiwan	PLoS ONE. 2012 Aug 24;7(8):Article number e43018.
2012-07	Genetic diversity of the mycobacterium tuberculosis Beijing family based on SNP and VNTR typing profiles in Asian countries	PLoS ONE. 2012 Jul;7(7):Article number e39792.
2012-07	Endoplasmic reticulum stress stimulates p53 expression through NF-kappaB activation	PLoS ONE. 2012 Jul;7(7):Article number e39120.
2012-06	Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9	Journal of Virology. 2012 Jun;86(12):6656-6667.
2012-06	Receptor binding surveillance of influenza clinical isolates	Future Virology. 2012 Jun;7(6):621-633.
2012-04	Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical features	Journal of Medical Virology. 2012 Apr;84(4):679-685.
2012-04	Type II ground glass hepatocytes Co-express HBsAg and HBx proteins and represent preneoplastic lesions	Journal of Hepatology. 2012 Apr;56(Suppl. 2):S181.
2012-03	Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer	International Journal of Cancer. 2012 Mar;130(6):1302-1313.
2012-02	Aberrant cyclin A expression and centrosome overduplication induced by hepatitis B virus Pre-S2 mutants and its implication in hepatocarcinogenesis	Carcinogenesis. 2012 Feb;33(2):466-472.
2012-01-05	Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement	Virology. 2012 Jan 5;422(1):132-143.
2012-01	Recombinant BCG coexpressing Ag85B, CFP10, and interleukin-12 induces multifunctional Th1 and memory T cells in mice	APMIS. 2012 Jan;120(1):72-82.
2012-01	Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle	Molecular and Cellular Biology. 2012 Jan;32(2):309-319.
2012-01	Selection and characterization of vaccine strain for Enterovirus 71 vaccine development	Vaccine. 2012 Jan;30(4):703-711.
2011-12	Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells	PLoS ONE. 2011 Dec;6(12):Article number e28977.
2011-11	A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of Enterovirus 71 in mice	PLoS ONE. 2011 Nov;6(11):Article number e27082.
2011-11	Exogenous interleukin-6, interleukin-13, and interferon-gamma provoke pulmonary abnormality with mild edema in enterovirus 71-infected mice	Respiratory Research. 2011 Nov;12:147.
2011-10	Novel feedback inhibition of surface antigen synthesis by Mammalian Target of Rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and therapy	Hepatology. 2011 Oct;54(4):1199-1207.
2011-09	An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: Epidemiology and diagnostic and genetic aspects	Journal of Medical Microbiology. 2011 Sep;60(9):1360-1365.
2011-07-01	A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery	Cancer. 2011 Jul 1;117(13):2951-2960.
2011-07	Epstein-Barr virus Zta-Induced immunomodulators from nasopharyngeal carcinoma cells upregulate interleukin-10 production from monocytes	Journal of Virology. 2011 Jul;85(14):7333-7342.
2011-06	Genomic instability caused by hepatitis B virus: into the hepatoma inferno	Frontiers in Bioscience. 2011 Jun;16(7):2586-2597.
2011-06	Effect of type 2 diabetes mellitus on the clinical severity and treatment outcome in patients with pulmonary tuberculosis: A potential role in the emergence of multidrug-resistance	Journal of the Formosan Medical Association. 2011 Jun;110(6):372-381.
2011-04	Analysis of global methylation using a Zta-expressing nasopharyngeal carcinoma cell line	Genomics. 2011 Apr;97(4):205-213.
2011-03	ACSL3 and GSK-3beta are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells	Journal of Cellular Biochemistry. 2011 Mar;112(3):881-893.
2011-03	Profiling of influenza viruses by high-throughput carbohydrate membrane array	Future Medicinal Chemistry. 2011 Mar;3(3):283-96.
2011-01	Dominant expression of survival signals of endoplasmic reticulum stress response in Hodgkin lymphoma	Cancer Science. 2011 Jan;(102)1:275-281.
2011	Prevalence of mycobacterium tuberculosis in Taiwan: A model for strain evolution linked to population migration	International Journal of Evolutionary Biology. 2011;2011:Article number 937434.
2010-10	Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma	Modern pathology. 2010 Oct;23(10):1393-1403.
2010-09	Endogenous latent membrane protein 1 in Epstein-Barr virus-infected nasopharyngeal carcinoma cells attracts T lymphocytes through upregulation of multiple chemokines	Virology. 2010 Sep;405(2):464-473.
2010-06	Hepatitis B virus surface antigen interacts with acid alpha-glucosidase and alters glycogen metabolism	Hepatology Research. 2010 Jun;40(6):633-640.
2010-04	BIOMED-2 protocols to detect clonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell lymphomas in southern Taiwan	Leukemia and Lymphoma. 2010 Apr;51(4):650-655.
2010-02	Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies	Molecular Immunology. 2010 Feb;47(5):1000-1009.
2010-01-05	Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase	Virology. 2010 Jan 5;396(1):1-9.
2010-01	Efficacy of peroxisome proliferator activated receptor agonist in the treatment of virus-associated haemophagocytic syndrome in a rabbit model	Antiviral Therapy. 2010 Jan;15(1):71-81.
2010-01	Comprehensive analyses and characterization of haemophagocytic lymphohistiocytosis in Vietnamese children	British Journal of Haematology. 2010 Jan;148(2):301-310.
2010-01	Reduced health provider delay and tuberculosis mortality due to an improved hospital programme	International Journal of Tuberculosis and Lung Disease. 2010 Jan;14(1):72-78.
2010-01	Hot spot mutation of hepatitis B virus pre-S2 gene related to hepatocellular carcinoma in Asian children	Child Care Health and Development. 2010 Jan;36(Suppl. 1):75.

產學合作
103	為進行與P1101長效型干擾素治療相關之國內醫學研究(藥華醫藥股份有限公司)
104	以新科技開發預防新陳代謝症候群及相關疾病的健康食品(綠加科技有限公司)
104	Evaluation of the Allianz Candidate Compound for the Chemoprevention and Therapy of Fatty Liver and Liver Cancer in A Transgenic Model Harboring HBV Pre-S2 mutant plus HBx Genes(有聯生技股份有限公司)

國科會計畫
102	肝再生SOCS家族基因在B型肝炎病毒致癌過程中所扮演的角色
104	B型肝炎e抗體陽性期的肝臟病理及肝內病毒複製研究並探討癌前期病變與抗病毒藥物治療的變化

技轉
104	HBV pre-S mutants chip and ELISA kit for the prediction of hepatocellular carcinoma.(普生生技公司)，技轉金1200萬元，權利金6%。

專利
專利名稱	發明人	日期	國家	編號
寡核苷酸用於偵測B型肝炎病毒PRE-S區域缺失及其用途	黃溫雅,蘇益仁,沈芳晴	2012.11.1	中華民國(TW)	I375723
Oligonucleotides and use thereof for determining deletion in HBV pre-S region	Huang W, Su IJ, Shen FC	2012.6.19	美國(USA)	US 2010/0003668 A1
Oligonucleotides and its Use Thereof for Deyerming Deletion in HBV Pre-S region		July 2, 2006	美國(USA)	EFS ID No. 3554706; Application No. 61077522
Anti-virus RNA ( 70001-020001 ) by siRNA ( HBV replication )		June 16, 2006	美國(USA)